Turco made her television acting debut in 1987, on the soap opera Guiding Light as Dinah Marler, going on to the soap opera All My Children as Melanie. She played the role of April O'Neil in Teenage Mutant Ninja Turtles II: The Secret of the Ooze and later in Teenage Mutant Ninja Turtles III. She guest starred in Party of Fiveas Annie Mott, a single mother who is also a recovering alcoholic, co-starred in The Agency as graphic artist Terri Lowell, and in the third season of Rescue Me as science teacher Mrs. Nell Turbody. Turco also appeared in the movie Invincible, playing Carol Vermeil, the wife of Dick Vermeil and also co-starred in the Walt Disney Picture The Game Plan.
　　In 2007, she was cast in the ABC TV series Big Shots, portraying Lisbeth, the ex-wife of Dylan McDermott's character, Duncan Collinsworth, a cosmetics company CEO. In addition, Turco is in a talent holding deal with ABC.[2] Turco played a guest-starring role in the second season of the Emmy-Award winning series Damages and will appear in CBS' Blue Bloods.[3]Most recently, she guest starred on Person of Interest as Zoe Morgan.